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Resource: http://www.lifespandynamics.com

Folic Acid Deficiency Linked to Parkinson's Disease

New research conducted by scientists at the National Institute on Aging suggests that folic acid deficiency could increase the brain’s susceptibility to Parkinson’s disease. In the finding, published in the January 2002 issue of the Journal of Neurochemistry, the investigators fed one group of mice a diet that included folate, while a second group was fed a diet lacking this vitamin. They then gave the mice moderate amounts of MPTP, a chemical that can cause Parkinson-like symptoms. In the mice fed folate, MPTP caused only mild symptoms of disease. But mice fed the folate-deficient diet developed severe Parkinson-like symptoms.

The scientists found that mice with low amounts of dietary folic acid had elevated levels of homocysteine in the blood and brain. They suspect that increased levels of homocysteine in the brain caused damage to the DNA of nerve cells in the substantia nigra, an important brain structure that produces dopamine. Loss of dopamine causes the nerve cells to dysfunction, leaving patients unable to direct or control their movement in a normal manner. In mice fed adequate amounts of folate, dopamine-producing nerve cells were able to repair damaged DNA and counteract the adverse effects of homocysteine. However, similar nerve cells in folate-deficient mice could not repair extensive DNA damage. As a result, these cells died.

“This is the first direct evidence that folic acid may have a key role in protecting adult nerve cells against age-related disease,” said Mark Mattson, Ph.D., chief of the NIA’s Laboratory of Neurosciences. “It is clear from this study that a deficiency of this vitamin is associated with increased toxin-induced damage to the dopamine-producing neurons in the mouse brain."

People who have Parkinson’s disease often have low levels of folic acid in their blood, but it is not clear whether this a result of the disease process or if they are simply malnourished due to their illness. But based on this study, Dr. Mattson speculates that consuming adequate amounts of folic acid—either in the diet or by supplementation—could help protect the aging brain against Parkinson’s and other neuro-degenerative diseases. Green leafy vegetables, citrus fruits and juices, whole wheat bread and dry beans are good sources of the vitamin. Food and Drug Administration (FDA) regulations require the addition of folic acid to enriched breads, cereals, flours, corn meals, pastas, rice, and other grain products.

Parkinson's disease occurs when certain nerve cells die or become impaired and can no longer produce dopamine. Without it, individuals can develop tremor or trembling in hands, arms, legs, jaw, and face; rigidity or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability or impaired balance and coordination. Patients may also have difficulty walking, talking, or completing other simple tasks. The disease is both chronic and progressive. Parkinson's is not usually inherited, but incidence of the disease increases with age, with an average onset at about 60 years. It afflicts about 50,000 Americans annually.


Elevated Homocysteine Levels and Risk for Dementia and Alzheimer's Disease

New research from scientists at Boston University reveals that elevated blood levels of the amino acid, homocysteine doubles the risk of developing dementia and Alzheimer’s disease. Cross-sectional studies have already shown that elevated plasma homocysteine levels are associated with reduced cognition and dementia. The new study establishes that the elevated homocysteine levels actually precede the onset of dementia by many years and are not just one of the multiple debilitating health effects of dementia. The results are highly suggestive that controlling plasma homocysteine levels in middle age can greatly reduce the risk of developing dementia in later years.

The study followed up on 1092 men and women subjects without dementia from the long-running Framingham Study. They were examined for total plasma homocysteine levels at base line and compared with levels measured eight years earlier at the start of the Framingham Study. The researchers used multivariable proportional-hazards regression to adjust for age, sex, apolipoprotein E genotype, vascular risk factors other than homocysteine, and plasma levels of folate and vitamins B12 and B6. The analysis revealed a significant positive correlation between earlier elevated homocysteine levels and frequency and severity of newly diagnosed dementia on follow-up. The report appeared in the Feb 14, 2002, issue of The New England Journal of Medicine. It provides the most compelling evidence yet of a causal association between high plasma homocysteine and later, significant memory loss and mental decline.

This research was conducted by Sudha Seshadri, M.D., Alexa Beiser, Ph.D., Jacob Selhub, Ph.D., Paul F. Jacques, Sc.D., Irwin H. Rosenberg, M.D., Ralph B. D'Agostino, Ph.D., Peter W.F. Wilson, M.D., and Philip A. Wolf, M.D.


Lowering Homocysteine Levels


There are two dietary supplements that have been conclusively demonstrated to significantly lower homocysteine levels. These include folic acid and trimethylglicene (TMG). Leafy green vegetables, citrus fruits, whole wheat bread and dry beans are good dietary sources of folic acid, that if taken in sufficient quantities can help to prevent excessive buildup of harmful homocysteine levels. Americans typically do not get sufficient dietary intake of folic acid to prevent dangerous levels of the amino acid. The Food and Drug Administration (FDA) now requires the addition of folic acid to enriched breads, cereals, flours, corn meals, pastas, rice, and other grain products. However many experts agree that higher levels of folic acid through supplementation may be required to reverse damaging homocysteine buildup.

TMG is a natural food substance found in sugar beets. Recent research has shown that TMG reduces homocysteine levels, by converting the harmful amino acid into the nontoxic anti-aging compound SAMe. The process, called methylation, joins a methyl group onto a cell DNA molecule. Methylation actually protects DNA from defective aging genes that cause diseases. The extra methyl group prevents these genes from being expressed in the cell body. Protecting the DNA may reduce the risk of genetically induced cancers and reduce cellular aging.

 
TMG (trimethylglicene) is a natural food substance found in sugar beets.

Good sources of folic acid include citrus fruits and juices, tomatoes, vegetables, and grain products such as bread, cereal, and pasta.

Vitamin B-6 is found in meat, poultry, fish, fruits, vegetables, and grain products, and vitamin B-12 is plentiful in meat, poultry, fish, and dairy products. You can get a sufficient amount of all three nutrients if you eat a varied, well-balanced diet.

Vitamin B-12 is found in
meat, eggs, or dairy products (animal products such as meat, shellfish, milk, cheese, and eggs)



Blindness Among the Elderly on the Rise – Early Detection and Treatment is Key

The National Eye Institute and Prevent Blindness America released a new report warning that blindness and visual impairment are increasing dramatically among older Americans. The report states that today more than one million Americans over the age of 40 are blind and that more than two million more have significant visual impairment. As the American population continues to age these statistics are expected to double in the next thirty years. Secretary of Health and Human Services Tommy G. Thompson stated that most eye disorders can be greatly reduced by early detection and treatment. "That's why eye health education programs that encourage those at high risk for eye disease to have regular dilated eye exams are essential in preventing vision loss. Healthy vision is a shared responsibility among the government, health care providers, community leaders, and the public." Visual impairment can be one of the most debilitating conditions severely impacting a person’s autonomy and ability to carry on many normal day to day tasks that people normally take for granted.

The leading causes of vision impairment and blindness in the U.S are: age-related macular degeneration, diabetic retinopathy, glaucoma, and cataracts. Age-related macular degeneration is the most common cause of blindness and vision impairment among Americans over the age of sixty, affecting more than one and a half million elderly Americans. It primarily affects that part of the retina of the eye that is responsible for sharp central vision. Research sponsored by the National Eye Institute has recently shown that vitamin C along with tocopherols and carotenoids can reduce the risk of advanced macular degeneration by 25 percent. To get the most complete natural tocopherol and carotenoid complex mixes at wholesale prices see the Life Span Anti-Cancer page.

Glaucoma causes visual impairment or blindness by gradually damaging the optic nerve. Typically loss of vision due to glaucoma is not experienced until after significant nerve damage has already occurred. It is estimated that half of all people with the disease are unaware of it. Today in America, among those over forty there are over two million diagnosed glaucoma cases, and about the same number of undiagnosed cases. Because most cases of the disease can be controlled and the loss of vision arrested by timely diagnosis and treatment, regular dilated eye exams are very important for anyone over forty who may be at risk. When vision is lost due to glaucoma it cannot be restored.

A number of research studies have shown that vitamin C supplementation significantly reduces elevated intraocular pressure in glaucoma cases. Doses from 2000 mg per day and ranging much higher have been tested. Higher doses of the vitamin are typically more effective than lower doses. Glaucoma patients are often instructed to take maximal daily doses of vitamin C to inhibit the disease. This involves gradually increasing dose levels until abdominal discomfort is noticed and then pulling back to a comfortable level. There is also some evidence that the anti-oxidant alpha lipoic acid, can improve visual function in some people with glaucoma. While these supplements may help inhibit progress of the disease, they do not cure the disease and must be used continuously to help control intraocular pressure.


Anti-Depressant Drugs Linked to Possible Cancer Risk

Can Prozac and similar drugs cause or aggravate brain tumors? This is the specter being raised by Professor John Gordon a researcher at Birmingham University. Dr Gordon’s research team has reported in the current issue of Journal Blood, that they have found direct evidence that a class of anti-depressant drugs (SSRI’s) may cause more vigorous growth of cancer tumors. The scientists discovered that in test-tube experiments, anti-depressant drugs such as Prozac stimulate the growth of a type of cancer called Burkitt's lymphoma. These drugs are known as selective serotonin re-uptake inhibitors (SSRI’s) and include Eli Lilly's Prozac, Lundbeck's Celexa, and GlaxoSmithKline's Paxil. Serotonin is an important mood controlling neurotransmitter that also appears to be a key catalyst in stimulating some types of apoptosis, a natural mechanism by which the body causes genetically damaged cancer cells to die. Professor Gordon said that these drugs appear to block the mechanism of cell apoptosis and although these results have only been demonstrated in test tube, the same mechanism could theoretically take place in people, resulting in more aggressive tumors. Previous work by Gordon and others has supported the concept that positive thinking can be integral to the body’s natural defenses against cancer. Serotonin, whose action is blocked by the anti-depressants, may be key to the “positive thinking” natural defense system.

Prozac-like anti-depressant drugs are currently used by millions of people worldwide and constitute one of the biggest classes of sellers for the international pharmaceutical industry. Spokesmen from the drug companies have said that there is no evidence whatsoever that these drugs pose any actual cancer risk in practice. They emphasized that there is no clinical evidence to back the theory and that the test tube results were likely caused by the high doses of the drugs used in Dr Gordon’s experimental study. Dr Gordon also stated that the results of the study are not conclusive that Prozac stimulates tumor growth. He said, “Although that extrapolation could be valid, there is no direct evidence from large scale epidemiological studies currently to back it up”.

If you are currently taking or plan to take SSRI’s such as Prozac you owe it to yourself to visit the Prozac Truth Website. You will find that the potential side effects of the drug, according to actual user experiences, may go far beyond anything that you might have imagined. For a natural healthy alternative to anti-depressant SSRI drugs see DHEA. For anti-cancer supplements that support natural cancer defense and cell apoptosis see the Life Span Anti-Cancer page.


FDA Warning - Arthritis Painkiller Linked to Meningitis

The FDA has issued a new warning about the painkiller Vioxx. The popular arthritis drug has been associated with seven cases of non-bacterial meningitis since May of 1999 when it was initially approved for acute pain relief. In seven cases, patients were using Vioxx when they developed the rare form of meningitis, but the report said that two of the cases lacked sufficient information to determine whether Vioxx was the cause. The manufacturer is now required by the FDA to list meningitis as a possible side effect of the drug.

This is not the first time that Vioxx and similar drugs have come under fire. In another study conducted by cardiologists at the Cleveland Clinic, and published in the Journal of the American Medical Association, both Vioxx and the equally popular Celebrex, showed an increased risk of heart attacks, blood clots and strokes. That study was based on previous clinical trial data published by the manufacturers. Vioxx and Celebrex were originally introduced and heavily marketed as breakthrough drugs with all the benefits of traditional arthritis NSAID drugs, but without the dangerous side effects. Vioxx and Celebrex are known as COX-2 inhibitors, which act as non-steroidal anti-inflammatories. But now in the study with over 8000 patients the risk of serious and life threatening cardiovascular problems, was more than double in the COX-2 inhibitors group compared with traditional NSAID drugs, which also have known cardiovascular risk problems. Furthermore the frequency of heart attacks in both Celebrex and Vioxx studies are significantly increased compared to other large studies with patients taking inert placebos. Many researches suggest that until more research is done with these drugs, that doctors should be cautious in prescribing either Celebrex or Vioxx to patients with any form of cardiovascular problem.

If you have osteo-arthritis, we encourage you to learn about liquid glucosamine complex and the Syn-Flex breakthrough. Liquid glucosamine goes far beyond just stopping the pain. It can actually halt the progression of osteoarthritis and unlike synthetic arthritis painkiller drugs, Syn-Flex is 100% natural and safe.

#034.0 TMG TriMethylGlycine Powder (aka Betaine Base) $16.00

Quantity & Dosage: 150 grams = 100 x 1.5 gram doses. Suggested daily dose of TMG is 500 mg – 1500 mg with other anti-homocysteine nutrients, Vits. B6, B12, & choline. Optimum dosage to raise SAMe levels is 2 grams 3 times a day.

TMG is a natural extract from sugar beets. Recent research has proven TMG to be a multi-faceted anti-aging substance with great cardio-vascular support. TMG literally rejuvenates cells through a process called methylation. This process joins a methyl group onto a cell DNA molecule.

  • Methylation reduces harmful homocysteine, thereby lowering the risk of heart disease and stroke. Methylation transforms homocysteine into nontoxic anti-aging compound SAMe.

  • Methylation produces SAMe, which has potent anti-aging effects. SAMe alleviates depression, regenerates the mylene of nerve cells, helps Alzheimer's and Parkinson's disease patients, and protects against live damage from alcohol abuse.

  • Methylation actually protects DNA from defective aging genes that cause diseases. The extra methyl group prevents these genes from being expressed in the cell body. Protecting the DNA may reduce the risk of genetically induced cancers and reduce cellular aging.

Summary of TMG Health Benefits

  • TMG helps metabolize fat in the liver

  • TMG lowers plaque-forming homocysteine. Researchers now believe that Homocysteine, much more than cholesterol, to be a cause of cardiovascular disease.
  • TMG naturally raises body levels of SAMe, a powerful anti-depressant compound required by your body
  • TMG increases detoxifying liver enzymes. This helps to cleanup the toxins released by the body when burning off fat.
  • TMG increases antioxidant glutathione levels. This helps to cleanup the toxins released by the body when burning fat.
  • TMG naturally raises body levels of anti-aging nutrient DMG. After cleaning up harmful plaque-forming homocysteine

The methylation process converts TMG to DMG with the added benefits :

  • DMG stimulates oxygen metabolism
  • DMG has antioxidant free radical protection
  • DMG lowers cholesterol
  • DMG improves heart and liver function
  • DMG reduces lactic acid
  • DMG increases lean body tissue

To order: http://www.lifespandynamics.com/111_9.htm

 

111.9 Folic Acid & TMG powder $14.00
27 grams TMG & 3000 mg Folic Acid
(This is equivalent to 3700 tablets of folic acid!)

Quantity & Dosage: 30 grams 10% Folic Acid & 90% TMG. = 300 x 100 mg dose. The quantity in our low price powder is equivalent to 3750 folic acid tablets from other companies!

Folic Acid and TMG spares brain cells through methylation. Methylation is an important bodily chemical process that is involved in many diverse parts of normal metabolism. It literally rejuvenates body cells by the joining of a methyl group to a DNA molecule. The process of DNA methylation is required for the normal maintenance of chromosomes. TMG spares brain choline for this use.

TMG is a natural extract from sugar beets. Recent research has proven TMG to be a multi-faceted anti-aging substance with great cardio-vascular support. TMG literally rejuvenates cells through a process called methylation. This process joins a methyl group onto a cell DNA molecule.

  • Methylation reduces harmful homocysteine, thereby lowering the risk of heart disease and stroke. Methylation transforms homocysteine into nontoxic anti-aging compound SAMe.

  • Methylation produces SAMe, which has potent anti-aging effects. SAMe alleviates depression, regenerates the mylene of nerve cells, helps Alzheimer's and Parkinson's disease patients, and protects against live damage from alcohol abuse.

  • Methylation actually protects DNA from defective aging genes that cause diseases. The extra methyl group prevents these genes from being expressed in the cell body. Protecting the DNA may reduce the risk of genetically induced cancers and reduce cellular aging.

Summary of TMG Health Benefits

  • TMG helps metabolize fat in the liver

  • TMG lowers plaque-forming homocysteine. Researchers now believe that Homocysteine, much more than cholesterol, to be a cause of cardiovascular disease.
  • TMG naturally raises body levels of SAMe, a powerful anti-depressant compound required by your body
  • TMG increases detoxifying liver enzymes. This helps to cleanup the toxins released by the body when burning off fat.
  • TMG increases antioxidant glutathione levels. This helps to cleanup the toxins released by the body when burning fat.
  • TMG naturally raises body levels of anti-aging nutrient DMG. After cleaning up harmful plaque-forming homocysteine

The methylation process converts TMG to DMG with the added benefits :

  • DMG stimulates oxygen metabolism
  • DMG has antioxidant free radical protection
  • DMG lowers cholesterol
  • DMG improves heart and liver function
  • DMG reduces lactic acid
  • DMG increases lean body tissue

To order: http://www.lifespandynamics.com/034_0.htm

 

508.9 ALPHA LIPOIC ACID Powder $34.50
Quantity & Dosage:
50 grams = 200 x 250 mg doses

ALPHA LIPOIC ACID has multi-faceted anti-aging properties. Known as the "Universal Anti-oxidant", it is both water and fat soluble and protects all areas of the body, including cell membranes. Lipoic acid is used by the body to recycle other anti-oxidants, such as vitamins E and C. It has insulin mimicking properties and protects from aging by glycation (cross-linking protein molecules by glucose and bound fructose). Lipoic acid enables the cells to provide more quick bursts of energy for exercise, reduces lactic acid buildup, and helps produce sustained energy without increasing fat production. Lipoic acid increases muscle density and size both for athletes and for elderly people who have difficulty maintaining muscle. It acts to speed creatine to muscle cells. Lipoic acid is found naturally in liver extract.

http://www.lifespandynamics.com/508_5.htm

 

Syn-Flex Breakthrough Formula

Syn-Flex is a breakthrough product in the fight against Osteoarthritis. It's unique, high quality, fast-impact formula provides rapid pain relief, cartilage protection, and overall joint health. Syn-Flex stops pain fast and in most cases halts the progress of osteoarthritis in ten to fifteen days. Syn-Flex comes with a thirty day money back guarantee, if you are not satisfied with the results.

Syn-flex contains the most powerful pain fighters available in any product in the U.S. market today. Besides pharmaceutical grade Liquid Glucosamine HCL and Glucosamine Sulfate, and eleven other synergistic ingredients are added to eliminate inflammation, restore damaged joints, ensure rapid pain relief, and protect cartilage.

The special Syn-Flex formula combines the latest scientific breakthroughs in the Arthritis medical community into one product that is guaranteed to end your pain and halt your osteoarthritis. Instead of difficult to absorb glucosamine pills and capsules, or short-lasting rub-on creams, Syn-Flex is a liquid formula for maximal absorption and long lasting complete arthritis pain relief.

Liquid Delivery Makes All The Difference
in Absorption and Bio-availability

New independent research shows that liquid delivery of glucosamine is much more effectiveUntil recently, glucosamine products were made available in two principal forms. Most were (and still are) in pill or capsule form. (Topical analgesics or products that are applied externally are used primarily for pain relief and not for cartilage rehabilitation.)

While it is true that the better quality topical analgesics will provide some temporary pain relief, they are clearly not designed to halt the progression of osteoarthritis. On the other hand, while pill and capsule formulas are used for both pain relief and for cartilage rehabilitation, they do not provide the optimum or full potential to heal and halt pain.  This is simply because most of the glucosamine and other ingredients taken in this form are not as accessible to be used by the body.  But liquid glucosamine HCL provides a base from which all ingredients of the complex (including the large Chondroitin Sulfate molecule) are readily taken up through the intestinal track, and used by the body to rebuild cartilage and connective tissue.

Over 95% of the pills and capsule formulas on the market today contain only about 10% glucosamine. More problematic is the quality of the glucosamine that is used by many manufacturers as well as the failure to incorporate other necessary ingredients such as  Chondroitin Sulfate that act synergistically to stop the pain and rebuild cartilage and connective tissue.  Most manufacturers have rushed to the market with incomplete glucosamine products in order to capture quick market share. This is has been a simple issue of putting profits before results.

Why Your Previous Glucosamine Products
May Not Have Worked

New independent research has demonstrated that in a different form you will achieve both faster pain relief and begin the process of rebuilding damaged cartilage more quickly. That new form is liquid.

Syn-Flex The Arthritis Remedy Breakthrough

Good sources of folic acid include citrus fruits and juices, tomatoes, vegetables, and grain products such as bread, cereal, and pasta.

TMG (trimethylglicene) is a natural food substance found in sugar beets.

Vitamin B-6 is found in meat, poultry, fish, fruits, vegetables, and grain products, and vitamin B-12 is plentiful in meat, poultry, fish, and dairy products. You can get a sufficient amount of all three nutrients if you eat a varied, well-balanced diet.

Vitamin B-12 is found in
meat, eggs, or dairy products (animal products such as meat, shellfish, milk, cheese, and eggs)

 

Amino Acids
Alanine
Arginine
Aspartic Acid
Cystine
Glutamic Acid
Glycine
Histidine
Leucine & Isoleucine
Lysine
Methionine
Phenylalaine
Proline
Serine
Taurine
Threonine
Tryptophan
Tyrosine
Valine

Herbs

Alfalfa

Aloe Vera

Blessed Thistle

Burdock Root

Capsicum or Cayenne

Cascara Sagrada or sacred bark

Chamomile

Chapparal

Comfrey

Echinacea

Euphrasia

Fo Ti

Garlic

Ginger

Ginseng

Gotu Kola

Hawthorne Berries

Hyssop

Licorice

Ma Haung

Mullein

Rose Hips

Sarsaparilla

Spirulina

Yellow Dock

Vitamins

Biotin

Choline

Folic Acid

Inositol

Niacinamide (Niacin - Vitamin B-3)

Paba

Pantothenic Acid

Vitamin A

Vitamin B-1

Vitamin B-12

Vitamin B-2 (Riboflavin)

Vitamin B-6

Vitamin B-17 (Laetrile)

Vitamin C (Ascorbic Acid)

Vitamin D

Vitamin E

Minerals

Calcium

Chromium

Copper

Iodine

Iron

Magnesium

Manganese

Potassium

Selenium

Trace Minerals

Zinc

Nutrients

Acidophilus

Bee Pollen

Bee Propolis

Bioflavonoids

B-Sitosterol

Grape Seed Extract

L-Carnitine

Lecithin

Octacosanol

Omega 3 Fatty Acids (EPA, DHA)

Phosphatidyl Choline

Pyc Nogenol (Pycnogenol)

RNA & DNA

Royal Jelly

  

You may use the LINKS provided to order, or you can checkout the prices in a store.

Also, Search the Web to find the lowest price possible. Just type the name of the product and the search engine will bring up numerous links.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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